Blue Dragon (Microsoft Game Studios, Mistwalker Inc.) von Hironobu Sakaguchi, Macher der Final Fantasy-Reihe, episches Rollenspiel.
Call of Duty 2 (Activision Publishing Inc., Infinity Ward), Zweiter Weltkriegs-Shooter.
Condemned : Criminal Origins (SEGA, Monolith Productions Inc.), Survival-Horror in Ego-Perspektive.
Dead or Alive 4 , (Tecmo Inc., Team Ninja), Beat'em Up.
DEAD RISING (Arbeitstitel, Capcom), Survival-Horror, Fotojournalist kämpft in Einkaufszentrum gegen Zombies.
The Elder Scrolls IV: Oblivion (Bethesda Softworks/2K Games, Bethseda Game Studios), Rollenspiel.
Full Auto (SEGA, Pseudo Interactive Inc.), Action-Racer mit Kampfelementen.
Gears of War (Microsoft Game Studios, Epic Games Inc.), taktische Action und Survival-Horror.
Kameo: Elements of Power (Microsoft Game Studios, Rare Ltd.), Action-Adventure mit Rollenspielelementen.
Lost Odyssey (Microsoft Game Studios, Mistwalker), episches Rollenspiel. Produziert von Hironobu Sakaguchi (Final Fantasy), Musik von Nobuo Uematsu (Final Fantasy-Komponist).
NINETY-NINE NIGHTS (Microsoft Game Studios, Q Entertainment/Phantagram Ltd.), Fantasy-Action von Tetsuya Mizuguchi (Space Channel 5, Rez).
The Outfit (THQ Inc., Relic Entertainment), teambasierte Action im Zweiten Weltkrieg.
Perfect Dark Zero (Microsoft Game Studios, Rare), Survival-Horror; Prequel zum Klassiker Perfect Dar.
Project Gotham Racing 3 (Microsoft Game Studios, Bizarre Creations Ltd.), Edel-Racer.
QUAKE 4 (Activision, id Software and Raven Software), Shooter.
Saint's Row (THQ, Volition Inc.) Gangster-Karriere in freier Spielwelt.
Test Drive Unlimited (Atari, Eden Games), Racer.
Madden NFL 06 (EA) Football.
Need for Speed Most Wanted (EA), Racer.
FIFA 06 (EA), Fußball.
Tiger Woods PGA TOUR 06 (EA), Golf.
Der Pate (EA), Action-Adventure.
NBA Live 06 (EA), Basketball.